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As we continue to improve our understanding of the drivers of cognitive decline—and as drugs that reduce amyloid and tau have failed to yield cognitive improvement—new therapeutic targets are being revealed and

Abnormal Neuronal Migration, Deranged Cerebral Cortical Organization, and Diffuse White Matter Astrocytosis of Human Fetal Brain

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Expected magnitude of effect, where documented: Skin elasticity (cutometry R2): +8% to +15% in small open-label series over six weeks Wound closure time: reduction of 1.2 to 2.3 days in animal models (not directly translatable to humans) Joint pain (visual analog scale): mean reduction of 1.5 to 2.0 points on a 10-point scale in retrospective chart reviews (high placebo susceptibility, no control group) The physician re-tests at defined intervals